Dissecting the Tumour Specificity of Cancer Drivers

 

The Challenge: Devise approaches to prevent or treat cancer based on mechanisms that determine tissue specificity of some cancer genes.
 

Background

 

Cancer is caused by mutations in the DNA of our cells. These mutations can come about by chance, or can be caused by environmental factors, and result in cells multiplying out of control. We know that different DNA mutations can cause different types of cancer. For example, mistakes in the BRCA1 and BRCA2 genes are known to have a role in breast and ovarian cancer development. However, despite decades of research, we don’t yet understand why these errors only cause cancer in specific organs, and not in other parts of the body. The faulty genes can be found in nearly all our cells – so why is the cancer found in specific places?

The Team

Multi-National Collaborators

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Hans Clevers

 

Professor of Molecular Genetics;
The Netherlands, Hubrecht Institute

>>more info

Stephen Elledge

 

Grand Challenge Shortlisted Team
Principal Investigator, Gregor Mendel Professor of
Genetics and of Medicine; USA, Harvard Medical School 
>>more info

Karen Cichowski

 

Professor of Medicine and Genetics; USA, Harvard Medical School

>>more info

Peter Park

 

Professor of Biomedical Informatics; USA, Harvard Medical School

>>more info

Trey Westbrook

 

Professor of Molecular and Human Genetics; USA, Baylor College of Medicine  >>more info

Owen Sansom

 

Director and Senior Group Leader at the CRUK Beatson Institute; UK, Deputy Director of the Institute of Cancer Sciences at the University of Glasgow and CRUK Glasgow Cancer Centre Lead, CRUK Beatson Institute and University of Glasgow

>>more info

Kevin Haigis

 

Director, Cancer Genetics; USA

Beth Israel Deaconess
Medical Center, Cancer Genetics 
>>more info

Kristian Helin

 

Director and Professor, Biotech Research and Innovation Centre (BRIC) and Novo Nordisk Foundation for Stem Cell Biology (DanStem), Denmark, University of Copenhagen  >>more info

Teresa Davoli

 

Assistant Professor in the Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology at New York University School of Medicine, USA  >>more info

Richard Marais

 

Director, CRUK Manchester Institute, Manchester, UK

>>more info

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